基本信息：

姓 名： 董婷

出生日期： 1989年12月23日

联系方式： tingdong2021@sdu.edu.cn；18854152103

工作单位： Kaiyun官方网站

通讯地址： 济南市文化西路44号Kaiyun官方网站天然药物化学研究所

个人简介：

董婷，生物化学与分子生物学博士，Kaiyun官方网站教授，齐鲁青年学者，博士生导师。主要从事天然产物重编程巨噬细胞用于免疫代谢疾病的机制研究。迄今为止申请人累计发表学术论文14篇，含第一／共同第一/通讯作者论文11篇，其中影响因子10分以上期刊论文7篇（2篇Nature Communications，1篇Journal of the American Chemical Society，2篇Angewandte Chemie International Edition，1篇Pharmacology & Therapeutics，1篇Journal of Advanced Research），参与申请国际专利2项，获得麻省理工学院博士后资助项目一项（MIT postdoctoral fellowship）。博士后期间在哈佛大学诺奖得主E. J. Corey教授实验室做短期化学生物学顾问。目前是国际学术期刊《Natural Products and Bioprospecting》、《Annals of Community Medicine and Primary Health Care》、IUBMB Life的编委，并担任多个SCI期刊的审稿人，包括PeerJ, Heliyon, Biomedicine & Phamacotherapy, Bone Research以及Internaltionl Journal of Oral Science。

教育背景：

2011-09 至 2016-06,  北京协和医学院, 生物化学与分子生物学 , 博士

2007-09 至 2011-06,  西北农林科技大学, 应用化学, 学士

研究经历：

2021 至今,  山东大学, kaiyun.com, 教授

2017 至 2021,  麻省理工学院，博士后

2016 至 2017,  哈佛医学院，哈佛大学干细胞与组织再生生物学系以及丹娜法伯癌症研究所，博士后

研究方向：

1. mRNA体内可视化工具的开发以及应用

2.免疫重编程抗衰老机制研究

承担课题：

1. 山东省海外优青，天然药物化学（No. 2022HWYQ-033），60万，2022.04-2025.03（在研）

2. 国家自然科学基金-青年项目，GPR3/β-arrestin2信号轴代谢重编程巨噬细胞的机制研究（No. 82204404）,30万，2023.01-2025.12（在研）

代表性文章：

Huirui Wang, Yinghui Gao, Li Wang, Yang Yu, Jiaozhen Zhang, Chunyu Liu, Yaxin Song, Haochuan Xu, Jingcheng Wang, Hongxiang Lou*, Ting Dong*(通讯). Lung specific homing of diphenyleneiodonium chloride improves pulmonary fibrosis by inhibiting macrophage M2 metabolic program. Journal of Advanced Research. 2022. https://doi.org/10.1016/j.jare.2022.04.012

Ting Dong^#, Xinyi Chen^#, Haochuan Xu, Yaxin Song, Huirui Wang, Yinghui Gao, Jingcheng Wang, Ruiqing Du, Hongxiang Lou*, Ting Dong*(通讯). Mitochondrial metabolism mediated macrophage polarization in chronic lung diseases. Pharmacology & Therapeutics, 2022 Nov; 239: 108208.

Yingzhong Li^#, Nikola A Ivica^#, Ting Dong^#(共一), Dimitrios P Papageorgiou, Yanpu He, Douglas R Brown, Marianna Kleyman, Guangan Hu, Walter W Chen, Lucas B Sullivan, Amanda Del Rosario, Paula T Hammond, Matthew G Vander Heiden, Jianzhu Chen. MFSD7C switches mitochondrial ATP synthesis to thermogenesis in response to heme. Nature. Communications, 2020, 11, 4837.

Guangan Hu*, Ting Dong, Sisi Wang, Hongyu Jing, and Jianzhu Chen*. Vitamin D3-Vitamin D receptor axis suppresses pulmonary emphysema by maintaining alveolar macrophage homeostasis and function. EBioMedicine, 2019, 45, 563-577.

Xiaohui Liu^#, Ting Dong^#(共一), Yu Zhou, Niu Huang and Xiaoguang Lei*. Exploring the Binding Proteins of Glycolipids with Bifunctional Chemical Probes. Angewandte Chemie International Edition, 2016, 55, 14330.

Ting Dong^#(共一), Chao Li^#, Xing Wang, Longyang Dian, Xiuguo Zhang, Lin Li, She Chen, Ran Cao, Li Li, Niu Huang, Sudan He* & Xiaoguang Lei*. Ainsliadimer A selectively inhibits IKKα/β by covalently binding a conserved cysteine. Nature Communications, 2015, 6, 6522.

Ting Dong, Weilong Liu, Zhirong Shen, Lin Li, She Chen & Xiaoguang Lei*. Pterisolic Acid B is a Nrf2 Activator by Targeting C171 within Keap1-BTB Domain. Scientific Reports, 2016, 6, 19231.

Ting Dong, Liao Daohong, Liu Xiaohui & Xiaoguang Lei*. Using Small Molecules to Dissect Non-apoptotic Programmed Cell Death: Necroptosis, Ferroptosis, and Pyroptosis. ChemBioChem 2015, 16, 2557.

Zhang Xiaoyun^#, Dong Ting^#(共一), Li Qiang, Xiaohui Liu, Xiaoying Yang & Xiaoguang Lei*. Second Generation TQ-Ligation for Cell Organelle Imaging. ACS Chemical Biology, 2015, 10, 1676.

Chao Li^#, Ting Dong^#(共一), Qiang Li & Xiaoguang Lei*. Probing the Anti-cancer Mechanism of (-)-Ainsliatrimer A through Diverted Total Synthesis and Bioorthogonal Ligation. Angewandte Chemie International Edition, 2014. 53, 12111.

Qiang Li^#, Ting Dong^#(共一), Xiaohui Liu & Xiaoguang Lei*. A Bioorthogonal Ligation Enabled by Click Cycloaddition of o‑Quinolinone Quinone Methide and Vinyl Thioether. Journal of the American Chemical Society, 2013, 135, 4996. (News story describing this work was highlighted in Chem. & Eng. News. 2013, 14, 37.)

Qiang Li, Ting Dong, Xiaohui Liu, Xiaoyun Zhang & Xiaoguang Lei*. ortho-Quinolinone Quinone Methide Finds its Applications in the Bioorthogonal Ligation. Current Organic Chemistry, 2014, 18, 86.

Chao Li, Ting Dong, Longyang Dian, Weidong Zhang & Xiaoguang Lei*. Biomimetic syntheses and structural elucidation of the apoptosis-inducing sesquiterpenoid trimers:(-)ainsliatrimers A and B. Chemical Science, 2013, 4, 1163.

专利：

Xiaoguang Lei, Chao Li, Ting Dong. Sesquiterpenoids, US patent, 20170044180, 02-06-2017.

Chen Jianzhu,Nikola,Li Yingzhong,Dong Ting. TARGET FOR MODULAT ING BODY MASS, US patent, WO 2022/051254 A2，10-03-2021.

会议报告：

特邀报告《2ND International Conference on Microbiology & Infectious Diseases》(2022)

麻省理工学术年会 (2019)

麻省理工学术年会 (2018)